The Cobra High Speed Sentry (H.I.S.S.) Tank has been the dominant tank used by Cobra forces since the organization's inception. The H.I.S.S. has been upgraded and remodeled over time, but all variants share a similar general design, featuring dorsal mounted cannons.

The HISS was developed to fulfill two separate needs on the battle field, anti-personnel and heavy armor. The H.I.S.S. tank is the most versatile and deadly opposition on any battlefield. Whether on city streets or through the dense jungle, the H.I.S.S. can outrun, out-maneuver, and out perform anything in its class. Built with a modular design allowing Cobra's technicians to easily replace and repair battle damaged units with maximum efficiency. Although specialized drivers are selected to pilot most H.I.S.S. tanks, the cockpit design is simple enough for almost any basic trooper to understand and operate.